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目的观察替吉奥联合三维适形放射治疗老年局部晚期食管癌的近期疗效和毒性反应。方法 49例不能或不愿手术的老年食管癌患者,随机分为联合组(替吉奥联合三维适形放射治疗)25例,对照组(单纯三维适形放射治疗)24例。两组均采用三维调强适形放疗,每周5次,每次2.0 Gy,总剂量为60~66 Gy。联合组在放疗第1天开始口服替吉奥胶囊40 mg/m2,2次/d,14 d为1个疗程,休息1周后继续口服第2个疗程。结果联合组和对照组放疗结束时获得有效率分别为88.0%和54.2%,两组有效率差异有统计学意义(P<0.05)。毒副作用主要为放射性食管炎、骨髓抑制、胃肠道反应、肝功能损伤等,联合组发生率略高于对照组,但两组差别无统计学意义(P均>0.05)。结论替吉奥联合三维调强适形放射治疗提高了老年局部晚期食管癌近期疗效,毒副作用轻,可耐受。
Objective To observe the short-term curative effect and toxicity of tegaserod combined with three-dimensional conformal radiotherapy in elderly locally advanced esophageal cancer. Methods Forty-nine elderly patients with esophageal cancer who were unable or unwilling to undergo surgery were randomly divided into 25 cases in combination group (TIGO combined with three-dimensional conformal radiotherapy) and 24 cases in control group (simple three-dimensional conformal radiotherapy). Two groups were used three-dimensional intensity modulated radiotherapy, 5 times a week, each 2.0 Gy, the total dose of 60 ~ 66 Gy. On the first day of radiotherapy, the combined group began oral administration of Teglitazone 40 mg / m2 twice daily for 14 days for one course of treatment and one week after the rest for oral administration for the second course of treatment. Results The effective rates of the combined group and the control group reached 88.0% and 54.2% respectively at the end of radiotherapy, the difference between the two groups was statistically significant (P <0.05). The main side effects were radiation esophagitis, myelosuppression, gastrointestinal reaction and liver injury. The incidence of combination group was slightly higher than that of the control group, but there was no significant difference between the two groups (all P> 0.05). Conclusion TGA combined with three-dimensional intensity-modulated conformal radiotherapy improves the short-term curative effect of elderly locally advanced esophageal cancer with light and side-effects.