潜伏相关抗原抗结核杆菌的潜在免疫原性

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在人类传染病中,结核病仍然严重威胁着人类健康,特别是在人类免疫缺陷病毒的出现和耐药菌株产生的情况下。鉴于目前唯一可用于接种的疫苗BCG产生不一致的效果,发展一种改进的TB疫苗是一种应该置于优先开发地位的国际研究领域。目前在临床试验中的候选疫苗还是接触前接种的疫苗,旨在阻止人一生中发生活动性结核病。据WHO报道,约三分之一的世界人口潜伏感染了结核杆菌。分枝杆菌休眠或潜伏与肉芽肿的形成有关,导致有助于细菌存活在 Among human infectious diseases, tuberculosis is still a serious threat to human health, especially in the presence of human immunodeficiency virus and drug-resistant strains. Given the inconsistent results of BCG, the only vaccine currently available for vaccination, developing an improved TB vaccine is an international research area that should be prioritized. Candidate vaccines currently in clinical trials are also pre-exposure vaccines designed to stop active tuberculosis throughout life. According to the WHO, about one third of the world’s population is potentially infected with Mycobacterium tuberculosis. Mycobacterial dormancy or latency is associated with the formation of granulomas, which leads to bacterial survival
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