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细胞凋亡在心血管疾病如动脉粥样硬化,缺血性心脏病,充血性心力衰竭中起着重要的作用。以往的研究已经证明氧化应激、生理应激、肿瘤坏死因子和Fas配体参与了心血管系统的细胞凋亡。而最近的研究证明了另一个凋亡相关因子,即颗粒酶B/穿孔蛋白系统也参与了心血管系统的细胞凋亡。在这篇综述中,我们阐述了颗粒酶B在心血管疾病中的作用,并且发现颗粒酶B抑制剂的实验应用可以减轻心血管病的发生发展,从而使抑制颗粒酶B/穿孔蛋白系统治疗心血管疾病成为可能。
Apoptosis plays an important role in cardiovascular diseases such as atherosclerosis, ischemic heart disease and congestive heart failure. Previous studies have demonstrated that oxidative stress, physiological stress, tumor necrosis factor and Fas ligand are involved in the apoptosis of cardiovascular system. However, recent studies have demonstrated that another apoptosis-related factor, granzyme B / perforin, is also involved in cardiovascular system apoptosis. In this review, we describe the role of granzyme B in cardiovascular disease and found that the experimental use of granzyme B inhibitors can reduce the development of cardiovascular disease, thereby inhibiting the enzyme granzyme B / perforin system for the treatment of heart Vascular disease is possible.