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肝癌(HCC)是世界上最常见也是我国高发的恶性肿瘤之一,全球每年约100万病例死亡,HCC发病率分别居我国男性和女性常见肿瘤的第三和第四位,全世界每年新发的HCC患者40%在我国。HCC恶性度较高,预后差,严重危害我国人民群众身体健康,现有的临床治疗技术疗效欠佳。目前的研究表明,HCC的发生发展和转移是一个由多种基因参与、相互作用,并受到多因素调节影响的复杂过程。许多癌基因、抑癌基因以及相关基因的激活或异常失活是肝癌发生的分子基础。因此利用基因工程手段进行肝
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in our country and one of the highest in our country. About one million deaths worldwide each year. The incidence of HCC is the third and fourth most common cancer in men and women in our country. 40% of HCC patients in our country. HCC has a high degree of malignancy and a poor prognosis, seriously endangering the health of Chinese people and people, and the curative effect of current clinical treatment technologies is poor. The current research shows that the development and metastasis of HCC is a complex process involving many genes, interacting and being influenced by many factors. Many oncogenes, tumor suppressor genes and related gene activation or abnormal inactivation of liver cancer is the molecular basis. Therefore, the use of genetic engineering for liver