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检测21例肝硬化患者红细胞膜中总磷脂及胆固醇。结果表明:肝硬化组红细胞膜中总磷脂含量显著低于正常对照组,而胆固醇却显著高于正常对照组(P均<0.01)。提示:肝硬化患者红细胞膜脂质更新障碍使脂质结构发生变化,从而使红细胞寿命明显缩短,并易在血管内发生溶血,这可能是肝硬化皆伴严重贫血的因素之一。说明在肝硬化患者治疗中,应重视治疗脂蛋白代谢紊乱。
Twenty-one patients with cirrhosis were tested for total phospholipid and cholesterol in erythrocyte membrane. The results showed that the content of total phospholipids in the erythrocyte membrane of cirrhosis group was significantly lower than that of the normal control group, but the cholesterol was significantly higher than that of the normal control group (all P <0.01). Hint: In patients with cirrhosis, dysfunction of lipid replacement of the erythrocyte membrane changes the lipid structure, which leads to the shortened life span of erythrocytes and easy hemolysis in the blood vessels, which may be one of the factors of cirrhosis with severe anemia. Description in the treatment of patients with cirrhosis, should pay attention to the treatment of lipoprotein metabolism disorder.