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目的:探讨改良尿道冲洗降低闭合性球部尿道损伤患者尿道狭窄的疗效。方法:回顾性分析2014年1月至2018年1月山西医科大学第一医院65例男性闭合性球部尿道损伤合并留置尿管困难患者的临床资料。其中，行软膀胱镜下导丝法留置导尿及尿道外口护理30例（常规组），行软膀胱镜下导丝法留置尿管及尿道药物冲洗35例（改良组），比较两组拔除尿管后1和6个月尿道狭窄发生率，拔除尿管后6个月扩尿道次数、最大尿流率，留置尿管期间疼痛视觉模拟评分（VAS）。结果:两组患者均成功留置尿管。留置尿管期间，改良组尿道外口分泌物量少而稀薄，常规组尿道外口分泌物量多而黏稠。两组拔除尿管后1个月尿道狭窄发生率和留置尿管期间VAS比较差异无统计学意义（n P>0.05）；改良组拔除尿管后6个月尿道狭窄发生率和扩尿道次数明显小于常规组[5.7%（2/35）比26.7%（8/30）和（7.1±1.0）次比（11.4±1.8）次]，拔除尿管后6个月最大尿流率明显大于常规组[（19.8 ± 2.9）ml/s比（16.3±2.3）ml/s]，差异有统计学意义（n P<0.05或0.05); the incidence of urethral stricture and number of urethral dilatation 6 months after catheter removal in improved group were significantly lower than those in routine group: 5.7% (2/35) vs. 26.7% (8/30) and (7.1±1.0) times vs. (11.4±1.8) times, the maximum urinary flow rate 6 months after catheter removal was significantly higher than that in routine group: (19.8 ± 2.9) ml/s vs. (16.3±2.3) ml/s, and there were statistical differences (n P<0.05 or <0.01).n Conclusions:The system of improved urethral irrigation can be easily fabricated and can achieve convenient application. This improved treatment can facilitate the discharge of urethral secretions, alleviate the urethral inflammation, reduce the urethral scar formation, and can prevent the incidence of bulbar urethral stricture effectively.