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本文研究了口服DMSA治疗30例铅中毒和16例铅吸收的疗效。应用DMSA 1.5g/d,连服3天停药4天为一个疗程,一般服用3个疗程。结果表明,其驱铅作用明显,铅中毒为治疗前的17倍,同时使血铅下降,δ-ALA降低,δ-ALAD活力恢复至正常水平,血FEP和ZPP也有下降趋势。除有轻微排锌作用外,对其他微量元素铜、镁、锰等无促排作用,对肝、肾、心等脏器无毒性影响。所以,DMSA是一种疗效肯定、副反应少、使用方便的新型口服驱铅药物,值得推广使用。
This paper studied the efficacy of oral DMSA in the treatment of lead poisoning in 30 patients and lead absorption in 16 patients. Application DMSA 1.5g / d, and even served 3 days for 4 days for a course of treatment, the general take 3 courses. The results showed that the lead-removing effect was obvious. Lead poisoning was 17 times before treatment. At the same time, blood lead, δ-ALA and δ-ALAD activity returned to normal levels. Blood FEP and ZPP also showed a decreasing trend. In addition to the role of a slight row of zinc, the other trace elements such as copper, magnesium, manganese and other emission-promoting effect on the liver, kidneys, heart and other organs without toxic effects. Therefore, DMSA is a new type of oral lead-removing drug with definite curative effect, few side reactions and easy to use, which is worth promoting.