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目的探讨腹腔镜结直肠癌手术对机体ET和NO的影响。方法选择2006年6月～2007年3月结直肠癌患者35例。分为腹腔镜组15例,开腹组20例。比较两组围手术期ET、NO及NO/ET的变化。结果两组患者性别、年龄、身高、体重差异无显著性(P>0.05)。腹腔镜组手术时间长于开腹组(P<0.05),出血量少于开腹组(P<0.05)。腹腔镜组术后第1天ET下降最显著(P<0.05),第3天恢复至术前水平,开腹组术后ET无显著变化。两组NO术后均明显下降(P<0.01),开腹组术后第2天,腹腔镜组术后第3天恢复至术前水平。NO/ET开腹组术后明显下降(P<0.01),术后第2天恢复,但术后第5天又明显下降;腹腔镜组术后第1天明显下降(P<0.01),术后第3天恢复至术前水平并再无波动。结论腹腔镜结直肠癌手术对机体血液动力学的稳定性影响较小。
Objective To investigate the effect of laparoscopic colorectal surgery on ET and NO in the body. Methods From June 2006 to March 2007, 35 patients with colorectal cancer were selected. Divided into laparoscopic group of 15 cases, open group of 20 cases. The changes of ET, NO and NO / ET during the perioperative period were compared between the two groups. Results There was no significant difference in gender, age, height and weight between the two groups (P> 0.05). Laparoscopic surgery longer than open group (P <0.05), bleeding less than the open group (P <0.05). In the laparoscopic group, ET decreased most significantly (P <0.05) on the first postoperative day, returned to the preoperative level on the third day, and no significant change was found in the laparoscopic group after the operation. The NO levels in both groups were significantly decreased (P <0.01). On the second day after operation, the laparoscopic group returned to the preoperative level on the third day after operation. NO / ET laparotomy significantly decreased (P <0.01) and recovered on the second day after operation, but decreased significantly on the fifth day after operation (P <0.01) 3 days after the return to preoperative level and no further fluctuations. Conclusions Laparoscopic colorectal surgery has little effect on hemodynamic stability.