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目的通过测定并比较极低出生体重伴支气管肺发育不良(BPD)与极低出生体重不伴BPD新生儿不同时期的血浆肿瘤坏死因子-α(TNF-α)水平,探讨TNF-α在BPD患儿血浆中的水平及临床意义。方法选取2012年8月-2013年12月在莱芜市妇幼保健院住院治疗并诊断为BPD的15名极低出生体重儿(VLBW)为实验组,选取同期资料完整的25名非BPD极低出生体重儿为对照组。采用ELISA法检测两组新生儿不同时期外周血血浆TNF-α水平,所得数据采用统计学软件SPSS13.0进行统计学分析。结果实验组患儿生后不同时期血浆TNF-α水平明显高于同时期对照组血浆TNF-α水平,差异有统计学意义(P<0.01)。结论 BPD患儿血浆TNF-α水平显著升高。
Objective To determine the level of TNF-α in plasma of different stages of very low birth weight (BPD) and very low birth weight Plasma levels and clinical significance in children. Methods Fifteen VLBW children hospitalized and diagnosed as BPD in Laiwu MCH from August 2012 to December 2013 were selected as the experimental group. Twenty-five non-BPD patients with complete absence of BPD Weight children as control group. The serum levels of TNF-α in peripheral blood of two groups of newborns at different periods were detected by ELISA. The data were statistically analyzed by SPSS13.0 software. Results The level of plasma TNF-α in experimental group was significantly higher than that in control group at the same period (P <0.01). Conclusion The level of plasma TNF-α in children with BPD is significantly higher.