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目的探讨硝苯地平对妊娠期高血压患者凝血酶指标、MAP、24h尿蛋白、TP、ALB水平的影响。方法将108例妊娠期高血压患者随机分为观察组和对照组各54例,对照组采用常规对症治疗,观察组在对照组基础上结合硝苯地平治疗,两组疗程均为14天,对比分析两组治疗前、后凝血酶指标、MAP、24h尿蛋白、TP、ALB水平变化。结果观察组PT、APTT治疗后较治疗前增加,而FIB较治疗前显著降低,PT、APTT显著高于对照组,而FIB显著低于对照组,差异均有统计学意义(P<0.05);两组MAP及24h尿蛋白水平治疗后较治疗前显著下降,观察组MAP及24h尿蛋白水平显著低于对照组,差异均有统计学意义(P<0.05);观察组TP及ALB水平治疗后较治疗前显著增加,观察组TP及ALB水平显著高于对照组,差异均有统计学意义(P<0.05)。结论硝苯地平作用于妊娠期高血压患者与改善凝血酶指标、降低MAP和24h尿蛋白水平、提升TP和ALB水平相关。
Objective To investigate the effect of nifedipine on thrombin, MAP, 24h urinary protein, TP and ALB in patients with gestational hypertension. Methods 108 patients with gestational hypertension were randomly divided into observation group and control group, 54 cases in each group. The control group was treated by conventional symptomatic treatment. The observation group was treated with nifedipine on the basis of the control group. The two groups were treated for 14 days. The changes of thrombin, MAP, 24h urinary protein, TP and ALB before and after treatment were analyzed. Results PT and APTT in observation group were higher than those before treatment, but FIB was significantly lower than before treatment, PT and APTT were significantly higher than those in control group, but FIB was significantly lower than that in control group (P <0.05). The level of MAP and 24h urinary protein in the two groups were significantly lower than those before treatment after treatment, and the difference was statistically significant (P <0.05). After the treatment of TP and ALB in the observation group Which was significantly higher than that before treatment. The levels of TP and ALB in the observation group were significantly higher than those in the control group (P <0.05). Conclusion Nifedipine can improve the indexes of thrombin, reduce the levels of MAP and 24h urinary protein and promote the correlation between TP and ALB in patients with gestational hypertension.