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本试验用健康日本大耳白兔45只,分为葱蜜酒(Ⅰ)、葱酒(Ⅱ)、蜜酒(Ⅲ)及白酒(Ⅳ)四组。酒剂用冷渍法,用药后临床症状Ⅰ及Ⅲ组腹胀明显。心电图Ⅱ导联波形比较恒定、明显。Ⅰ组用药后P波呈明显上升趋势,T波则明显下降。Ⅱ、Ⅲ、Ⅳ组T波和P波的变化不如Ⅰ组明显。病理组织学变化:Ⅰ组心肌炎最明显(有充血、出血、颗粒变性、心肌纤维断裂,炎性浸润等),Ⅱ组个别家兔有明显心肌灸,炎性细胞浸润较轻,Ⅲ组病变轻微,Ⅳ组病变不明显。
In this experiment, 45 healthy Japanese rabbits were used. They were divided into four groups: onion honey wine (I), green onion wine (II), honey wine (III) and white wine (IV). The cold-staining method was used for alcoholic drinks, and abdominal distension was evident in clinical symptoms I and III after administration. ECG II lead waveform is relatively constant and obvious. In Group I, the P wave showed a significant upward trend, while the T wave decreased significantly. The changes of T wave and P wave in group II, III and IV were not as obvious as those in group I. Histopathological changes: In group I, myocarditis was most obvious (congestion, hemorrhage, granular degeneration, myocardial fibrosis, inflammatory infiltration, etc.). In group II, individual rabbits had obvious myocardial moxibustion, inflammatory cell infiltration was lighter, and group III lesions were mild. The lesions in group IV were not obvious.