论文部分内容阅读
以往实验结果表明,正常小鼠全身照射后红系造血的开始时间与一定范围的照射剂量成正比。本实验的目的是研究 W/W~v 和 SL/SL~d 两个种系有遗传缺陷的再生障碍性贫血的小鼠对全身照射后的反应是否相同。实验用(WB×B_6)_f_1-W/W~v 和(WC×B_6)_f_1-SL/SL~d 小鼠,并以同窝小鼠(WB×B_6)_f_1-+/+或(WC×B_6)_f_1+/+为对照,每组5～10只,用X 线照射,剂量率为100拉德/分,分别于照后3～12天和3～16天从眼眶静脉窦取血,进行网织红细胞计数和红细胞比积测定。并以网织红细胞降至最低值后持续升高的开始时间作为红系造血的开始时间。实验结果:W/W~v 小鼠,100或200拉德照射后网织红细胞降到最低值(0～0.3%)之后,随之发
Past experimental results show that the normal mouse erythrocytic hematopoietic irradiation after the start of a certain range of dose proportional to the total dose. The purpose of this experiment was to investigate whether the response to systemic irradiation in mice with aplastic anemia with genetic defects in both W / W ~ v and SL / SL ~ d lines was the same. (WB × B_6) _f_1-W / W ~ v and (WC × B_6) _f_1-SL / SL ~ d mice were treated with WB × B_6 _f_1 - + / + B_6) _f_1 + / + as control, each group of 5 to 10, with X-ray irradiation, the dose rate of 100 rad / min, respectively, after 3 to 12 days and 3 to 16 days after taking blood from the orbital sinus, Reticulocyte count and hematocrit measurements. And red blood cells to the lowest sustained rise after the starting time as red blood cells start time. Experimental Results: After W / W ~ v mice, reticulocytes were reduced to the lowest value (0 ~ 0.3%) after 100 or 200 rad irradiation,