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目的探讨Survivin在鼻咽癌患者中的表达情况及其相关性。方法选择30例经病理组织学证实为鼻咽癌的患者为研究对象,并选择30例鼻咽黏膜慢性炎为对照组,采用免疫组化法测定两组鼻黏膜标本中Survivin表达情况及采用RT-PCR法测定两组Survivin的表达量,并分析彼此间的相关性。结果 Survivin的相对表达量:对照组(0.07±0.04)、Ⅰ期鼻咽癌(1.14±0.21)、Ⅱ期鼻咽癌(1.37±0.27)、Ⅲ期鼻咽癌(1.59±0.34),Ⅳ期鼻咽癌(1.82±0.41),两两相比差异有统计学意义(P<0.05)。鼻咽癌组织中Survivin阳性表达率显著高于对照组,差异有统计学意义(P<0.05)。结论 Survivin可能参与到鼻咽癌肿瘤的发生及发展过程中,通过测定Survivin表达强度对预测鼻咽癌病情有重要的意义。
Objective To investigate the expression of Survivin in patients with nasopharyngeal carcinoma and its correlation. Methods Thirty patients with nasopharyngeal carcinoma confirmed by histopathology were selected as study objects. Thirty patients with chronic nasopharyngeal mucosal inflammation were selected as the control group. The expression of Survivin in the two groups of nasal mucosa specimens was detected by immunohistochemistry and RT - The expression of Survivin in the two groups was measured by PCR, and the correlation between them was analyzed. Results The relative expression of Survivin in control group (0.07 ± 0.04), stage Ⅰ nasopharyngeal carcinoma (1.14 ± 0.21), stage Ⅱ nasopharyngeal carcinoma (1.37 ± 0.27), stage Ⅲ nasopharyngeal carcinoma (1.59 ± 0.34), stage Ⅳ Nasopharyngeal carcinoma (1.82 ± 0.41), any difference between two groups was statistically significant (P <0.05). The positive rate of Survivin in NPC was significantly higher than that in control group (P <0.05). Conclusion Survivin may be involved in the occurrence and development of nasopharyngeal neoplasms. Survivin expression may play an important role in the prognosis of NPC.