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成人Ｔ细胞白血病（ＡＴＬ）由人类Ⅰ型嗜Ｔ细胞病毒（ＨＴＬＶ－Ⅰ）引起，但其发病机理仍不清楚。我们应用逆转录－多聚酶链反应结合直接序列分析检测１０例ＡＴＬ患者的Ｎ－ｒａｓ基因，结果在一例ＡＴＬ发现Ｎ－ｒａｓ６１位点突变（ＣＡＡ→ＣＴＡ），说明ＨＴＬＶ－Ⅰ感染之后有多种因素参与ＡＴＬ的发病。
Adult T-cell leukemia (ATL) is caused by human type I T-cell virus (HTLV-I), but its pathogenesis remains unclear. We detected the N-ras gene in 10 patients with ATL by reverse transcription-polymerase chain reaction combined with direct sequence analysis. The results showed that there was a mutation in the ATL (CAA → CTA) in ATL, indicating that there are many factors after HTLV-Ⅰ infection Participate in the pathogenesis of ATL.