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近年来,各种疾病并发血栓栓塞症的现象日益增多。血栓形成是术后和产后以及心脏血管系统疾病时最常见的死亡原因之一。血管内血栓形成的发病机制,尚未完全阐明。前一世纪已提出它是血流速度减慢、血管壁和血液成分的改变的后果。这设想目前仍得到承认。一、各种原因在血管内血栓形成的发病机制中的意义1.血管壁损害和血管内血栓形成:根据Cop-ley 的意见,血管内皮经常复有一层纤维蛋白簿膜,并且不断生成和破坏。这层薄膜可降低血液的粘滞性和凝固性,并阻止血液有形成分粘附于血管壁,从而保证血液循环。有人发现,纤维蛋白在血管的生理性损伤部位不断生成。Nolf 指出,
In recent years, various diseases complicated by thromboembolism are increasing. Thrombosis is one of the most common causes of death during postoperative and postpartum periods and in the treatment of cardiovascular and vascular diseases. The pathogenesis of intravascular thrombosis has not yet been fully elucidated. The previous century has suggested that it is a consequence of a slowed blood flow, altered blood vessel wall and blood composition. The idea is still being recognized. First, a variety of reasons for the pathogenesis of intravascular thrombosis significance 1. Vessel wall damage and intravascular thrombosis: According to Cop-ley’s opinion, the vascular endothelium often with a layer of fibrin membrane, and continue to generate and destroy . This film can reduce the blood viscosity and coagulation, and prevent the blood forming components attached to the vessel wall, thus ensuring blood circulation. It was found that fibrin in the vascular physiological injury sites continue to produce. Nolf points out,