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我们在以前的报道中曾提出对Biro所创始的实验方法略加改变之后,用兔建立了一个简便的适于作药物筛选急性实验的脑缺氧模型。 利用这种模型在过去四年里对十四种中西药做了200次筛选实验。十四种药物中能提高耐缺氧效果达50％,而且作用比较持久的只有戊巴比妥钠和舒乐安定。前者的效果已为大多数神经内外科医师所承认。关于后者,自从在国内仿制成功以来,临床工作者已熟知它为较好的安定剂。这次通过筛选实验,发现它还有可与戊巴比妥钠媲美的抗缺氧效果,它的突出优点是既无明显的麻醉作用又不抑制呼吸。
In a previous report that we proposed a slight change to the experimental method invented by Biro, we used rabbit to establish a simple model of cerebral hypoxia suitable for acute drug screening experiments. Using this model, we conducted 200 screening experiments on fourteen Chinese and Western medicines in the past four years. Fourteen drugs can improve the anti-hypoxia effect of up to 50%, and the role of more lasting only pentobarbital sodium and zolalezepine. The effect of the former has been recognized by most neurosurgeons. With regard to the latter, clinicians have become familiar with it as a good stabilizer since the successful imitation in the country. This time through the screening experiments and found that it is comparable with pentobarbital sodium anti-hypoxia effect, its outstanding advantage is that there is no obvious anesthetic effects and does not inhibit breathing.