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用放免方法测定58例肺心病患者和41例正常人血清内源性洋地黄样因子(EDF)浓度。结果发现,肺心病急性发作期患者血清EDF浓度明显低于正常人(P<0.01),缓解期明显升高;血清EDF浓度与心功能不全严重性、PaC0_2呈明显负相关,与Pa0_2呈明显正相关(P分别<0.01、<0.05、<0.01);病程、肝、肾功能状态、血pH值对血清EDF浓度有明显影响(P<0.05～0.02)。
The serum endogenous digitalis-like factor (EDF) concentrations in 58 patients with pulmonary heart disease and 41 normal individuals were determined by radioimmunoassay. The results showed that serum EDF concentration in patients with acute episode of pulmonary heart disease was significantly lower than that in normal people (P <0.01), and significantly increased in remission stage. Serum EDF concentration was negatively correlated with severity of cardiac insufficiency, PaCO 2 and PaO 2 (P <0.01, <0.05, <0.01). The course of disease, liver and renal function and blood pH had significant effects on the serum EDF concentrations (P <0.05-0.02).