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有报道认为,骨髓增生异常综合征(MDS)病人骨髓活检(BMB)中原始细胞成群出现或严重骨髓纤维化(BMF)是预后不良的指征,为评价BMB的某些组织学参数的预后意义,作者对106例MDS病人的BMB结果进行了回顾性分析。男性73例,女性33例,年龄35～79岁(中数61岁)。BMB组织学评价参数包括细胞增生或减少、BMF程度以及原始细胞浸润方式等。BM中原始细胞浸润有三种方式:(1)弥漫型:原始细胞数量增多但无成团趋势;(2)簇型(Cluster):原始细胞成群分布,每群细胞小于6个;(3)大簇型:原始细胞成群且每群细胞大于6个。
It is reported that myeloid bone marrow biopsy in patients with myelodysplastic syndrome (MDS) cluster of blast cells or severe bone marrow fibrosis (BMF) is an indication of poor prognosis, in order to evaluate the prognosis of some histological parameters of BMB Significance, the author of 106 cases of MDS patients with BMB results were retrospectively analyzed. 73 males and 33 females, aged 35-79 years (median 61 years). BMB histological evaluation parameters include cell proliferation or reduction, BMF degree and the primitive cell infiltration and so on. There are three ways to infiltrate the primitive cells in BM: (1) diffuse type: the number of primitive cells increases but no agglomeration tendency; (2) Cluster: the primitive cells are distributed in groups and each group of cells is less than 6; (3) Large tufts: Protocells are clustered and more than 6 per group of cells.