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目的：进一步了解大肠癌患者的异常免疫状态，探讨ｓＴＮＦＲⅠ检测的临床意义。方法：用双单抗夹心酶联免疫吸附法检测ｓＴＮＦＲⅠ含量。结果：大肠癌Ｃ期、Ｄ期病人的血ｓＴＮＦＲⅠ浓度显著高于正常对照，为１３０１９０±１３７９２０ｕ／Ｌ、２０７４００±１３７３９０ｕ／Ｌ比５１６４０±２６６７０ｕ／Ｌ。ｓＴＮＦＲⅠ升高程度及异常发生率与肿瘤分期、血ＣＥＡ的异常率有关，而与肿瘤的分化程度无关。结论：ｓＴＮＦＲⅠ的检测对协助大肠癌的早期诊断、病人复发随访及预后判断具有实用价值。
Objective: To further understand the abnormal immune status of patients with colorectal cancer and to explore the clinical significance of sTNFRI detection. Methods: The content of sTNFRI was detected by enzyme-linked immunosorbent assay with double monoclonal antibody. Results: The serum sTNFRI concentration in patients with colorectal cancer at stage C and stage D was significantly higher than that of the normal control, which was 130190±137920u/L and 207400±137390u/L compared with 51640±26670u/L. The increase in sTNFRI and the incidence of abnormalities were related to tumor stage and abnormal rate of CEA in blood, but not to the degree of tumor differentiation. Conclusion: The detection of sTNFRI has practical value in assisting early diagnosis of colorectal cancer, follow-up of patient recurrence and prognosis.