论文部分内容阅读
研究大肠癌患者围手术期的免疫状态。应用流式细胞仪检测３５例大肠癌患者手术前后Ｔ细胞表面６种抗原标志，并与良性病变患者进行对比分析。结果大肠癌患者术前ＣＤ３、ＣＤ４、ＣＤ４／ＣＤ８、ＣＤ１６、ＣＤ６９均低于对照组，ＣＤ８高于对照组（Ｐ＜０．０５），ＣＤ３＋／ＨＬＡ－ＤＲ＋与对照组相同；术后ＣＤ８降低，ＣＤ３、ＣＤ４、ＣＤ４／ＣＤ８、ＣＤ１６、ＣＤ６９、ＣＤ３＋／ＨＬＡ－ＤＲ＋均升高（Ｐ＜０．０５），活化Ｔ细胞ＣＤ３＋／ＨＬＡ－ＤＲ＋明显高于对照组（Ｐ＜０．０１）。大肠癌患者术前免疫功能低下，术后活化Ｔ细胞明显增多，切除肿瘤有益于改善患者细胞免疫功能，故减瘤手术是必要的。
To study the perioperative immune status of patients with colorectal cancer. Flow cytometry was used to detect the six antigenic markers of T cells on the surface of 35 colorectal cancer patients before and after surgery, and compared with benign lesions. Results The preoperative CD3, CD4, CD4/CD8, CD16, and CD69 were lower in patients with colorectal cancer than in the control group. CD8 was higher than that in the control group (P<0.05). CD3+/HLA-DR+ was the same as in the control group; , CD3, CD4, CD4/CD8, CD16, CD69, CD3+/HLA-DR+ all increased (P<0.05), activated T cells CD3+/HLA-DR+ were significantly higher than the control group (P<0.01). Preoperative immune function is low in patients with colorectal cancer, postoperative activation of T cells increased significantly, removal of tumors is beneficial to improve the patient’s cellular immune function, so tumor reduction surgery is necessary.