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用不同剂量尿烷一次腹腔注射，对ＫＭ、ＢＡＬＢ／ｃ和Ａ／Ｊ系小鼠进行肺肿瘤短期诱发试验，以比较其敏感性，为环境化学物致癌性鉴定的实验条件提供依据。结果显示：以肺肿瘤发生率和平均发瘤数两项指标来衡量发瘤危险，Ａ／Ｊ系均在最低染毒剂量（２５ｍｇ／ｋｇ）即出现发瘤危险明显增高；ＫＭ系以发生率衡量时，１００ｍｇ／ｋｇ为发瘤危险增高的最低剂量，而以平均发瘤数衡量时，最低剂量为２００ｍｇ／ｋｇ；ＢＡＬＢ／ｃ系前者为２００ｍｇ／ｋｇ，而后者则大于２００ｍｇ／ｋｇ。因此，可以认为这三个品系小鼠对诱发肺肿瘤的敏感性为Ａ／Ｊ＞ＫＭ＞ＢＡＬＢ／ｃ。
Intraperitoneal injection of different doses of urethane was used to induce short-term induction of lung tumors in KM, BALB/c and A/J mice to compare their sensitivities and to provide basis for the experimental conditions for the identification of carcinogenicity of environmental chemicals. The results showed that the risk of tumors was measured by the incidence of lung tumors and the average number of tumors. The risk of tumors was significantly increased at the lowest dose (25 mg/kg) in A/J strains; the incidence of KM was increased. When measured, 100 mg/kg was the lowest dose at which the tumor risk increased, and when measured as the average number of tumors, the lowest dose was 200 mg/kg; the former was 200 mg/kg in the BALB/c strain and the latter was greater than 200 mg/kg. Therefore, it can be considered that the sensitivity of the three strains of mice to lung tumor induction is A/J>KM>BALB/c.