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目的:观察两性霉素B脂质体治疗深部真菌感染的临床疗效。方法:应用两性霉素B脂质体无菌冻干制剂,从1mg/d起逐渐加量至1mg/(kg·d)左右维持治疗至深部霉素感染被控制,甚至病原体转阴。结果:30例各系统严重疾病合并深部真菌感染患者中,有19例在用药3～60天病原体转阴,痊愈19例(占63.3％),显效9例(占30.0％),进步1例(占3.3％),无效1例(占3.3％),总有效率达96.7％。结论:两性霉素B脂质体治疗各系统严重疾病合并真菌感染疗效显著,与传统应用游离两性霉素B相比,疗效更好,疗程更短,毒副反应发生率明显降低。
Objective: To observe the clinical efficacy of amphotericin B liposome in the treatment of deep fungal infection. Methods: The amphotericin B liposomal sterile lyophilized preparation was gradually added from 1mg / d to 1mg / (kg · d) or so to maintain the treatment until the deep mycophenolate infection was controlled, even the pathogen turned negative. Results: Thirty-nine patients (63.3%) were cured from pathogens of 3 to 60 days after medication, 19 cases were markedly effective (30.0%), 1 case was improved Accounting for 3.3%), 1 invalid (3.3%), the total effective rate was 96.7%. CONCLUSION: Amphotericin B liposomes have a significant therapeutic effect on severe diseases and fungal infections in every system. Compared with traditional application of free amphotericin B, amphotericin B liposome has better curative effect, shorter course of treatment and lower incidence of toxic and side effects.