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目的研究T淋巴细胞活化因子对系统性红斑狼疮(systemic lupus erythematosus,SLE)患者造血系统生长的影响。方法采集15例SLE患者及对照组的骨髓标本,测定其免疫表型(CD3-PC5、CD34-PE/CD38-FITC,CD69-PE/HLA-DR-FITC)及培养骨髓单个核细胞。结果SLE患者骨髓T细胞上CD69、HLA-DR表达较对照组增高(P<0.05),骨髓单个核培养结果无显著性差异(P>0.05)。结论SLE患者T细胞自身功能出现了异常活化,但对造血系统并无明显影响。
Objective To investigate the effect of T lymphocyte activation factor on hematopoietic system in patients with systemic lupus erythematosus (SLE). Methods Bone marrow specimens of 15 SLE patients and control group were collected and their immunophenotypes (CD3-PC5, CD34-PE / CD38-FITC) and bone marrow mononuclear cells were detected. Results The expression of CD69 and HLA-DR in bone marrow T cells of SLE patients was higher than that of the control group (P <0.05). There was no significant difference in bone marrow mononuclear cells (P> 0.05). Conclusion The abnormal function of T cells in patients with SLE is abnormal, but there is no obvious effect on the hematopoietic system.