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临床上应用雄激素（睾酮）治疗功能性子宫出血，子宫肌瘤和慢性肾病等，用量大，疗程长，且能引起肾功能障碍。为了阐明肾损伤的病理组织学基础，我们给雌性小鼠以大剂量雄激素，用光镜和电镜观察了肾脏的病理组织学和超微病理学改变，并测定了肾小体、血管球和肾小管的形态计量学参数，结果显示：肾小体和肾小管，特别是滤过膜和近曲小管上皮均有十分明显的细胞和亚细胞水平改变；近曲小管的截面积、等效体积、周长、最大直径、最小直径、等效直径和形状因子等７项参数与正常对照组相比，也有十分显著的差异。因此，在长期大剂量应用雄激素时必须重视其对肾脏的损伤
Clinical application of androgen (testosterone) treatment of functional uterine bleeding, uterine fibroids and chronic kidney disease, large dosage, long course of treatment, and can cause renal dysfunction. In order to elucidate the histopathological basis of renal injury, we used high-dose androgen to female mice to observe the histopathological and ultrastructural changes of the kidneys by light and electron microscopy. The renal, The morphometric parameters of the renal tubules showed that the changes of the cellular and subcellular levels of the renal tubules and tubules, especially the filtration membrane and the proximal tubule epithelium, were very obvious. The cross-sectional area of the proximal tubule and the equivalent volume , Circumference, maximum diameter, minimum diameter, equivalent diameter and shape factor and other seven parameters compared with the normal control group, there are very significant differences. Therefore, in the long-term high-dose androgen must pay attention to its damage to the kidneys