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目的:评价氨溴索与地塞米松联用对新生儿重症吸入性肺炎患儿的临床疗效。方法:选取2012年1月—2015年5月收治的重症吸入性肺炎新生儿60例为研究对象,将其分为观察组患者和对照组患者,各30例;对照组患者患者均给予地塞米松和常规治疗,观察组患者患者在对照组患者治疗基础上加用氨溴索治疗,评价两组患者治疗后的总有效率和机械通气时间、氧疗时间以及住院时间。结果:治疗后,观察组患者患儿的总有效率为86.67%显著高于对照组患者为26.67%(P<0.05);机械通气时间、氧疗时间及住院时间分别为(0.85±0.63)d,(1.26±0.96)d和(5.21±1.20)d,低于对照组患者分别为(1.99±0.54)d,(2.35±1.02)d和(8.96±2.61)d(P<0.05)。结论:氨溴索与地塞米松联用治疗新生儿重症吸入性肺炎,疗效确切,方法简单,临床闻效优于单用地塞米松治疗。
Objective: To evaluate the clinical efficacy of combination of ambroxol and dexamethasone in infants with severe aspiration pneumonia. Methods: Sixty newborn infants with severe aspiration pneumonia admitted from January 2012 to May 2015 were selected as study subjects and divided into observation group and control group, with 30 cases in each group. Patients in control group were given dexamethasone In the control group, patients in the observation group were treated with ambroxol, and the total effective rate and duration of mechanical ventilation, oxygen therapy time and hospital stay after treatment were evaluated. Results: After treatment, the total effective rate in the observation group was 86.67%, which was significantly higher than that in the control group (26.67%, P <0.05). The duration of mechanical ventilation, oxygen therapy and hospital stay were (0.85 ± 0.63) d , (1.26 ± 0.96) d and (5.21 ± 1.20) d, respectively, which were lower than those in the control group (1.99 ± 0.54) d, (2.35 ± 1.02) d and (8.96 ± 2.61) d, respectively. Conclusion: Combination of ambroxol and dexamethasone can treat neonatal severe aspiration pneumonia. The curative effect is exact, the method is simple and the clinical efficacy is better than that of dexamethasone alone.