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目的:研究Survivin、Caspase-3及p53在喉鳞状细胞癌手术切缘中的表达意义及相关性。方法:116例患者术后按肿瘤复发情况分成4组,分别为:复发≤1年组,>1~3年组,>3~<5年组,≥5年组(包括5年后无复发),应用免疫组织化学方法检测手术切缘Survivin、Caspase-3及p53的表达情况。结果:Survivin在4组中的表达分别为92.9%、85.0%、50.0%及21.1%(P<0.01);Caspase-3在4组中的表达分别为50.0%、50.0%、66.7%及89.5%(P<0.01);p53在4组中的表达分别为57.1%、37.5%、45.8%及18.4%(P<0.05);Sur-vivin、Caspase-3及p53在4组的表达均有统计学意义。结论:喉癌手术切缘中Survivin、Caspase-3及p53的表达在喉鳞状细胞癌的发生、发展中可能起重要作用,并对喉鳞状细胞癌的早期诊断和预后判断有意义。
Objective: To investigate the significance of expression of Survivin, Caspase-3 and p53 in the surgical margins of laryngeal squamous cell carcinoma. Methods: One hundred and sixty-six patients were divided into 4 groups according to the tumor recurrence after operation: recurrence ≤ 1 year group,> 1-3 years group,> 3 ~ <5 years group, ≥ 5 years group (including no recurrence after 5 years ), The expression of Survivin, Caspase-3 and p53 in surgical margin was detected by immunohistochemical method. Results: The expressions of Survivin in the four groups were 92.9%, 85.0%, 50.0% and 21.1% respectively (P <0.01), while the expressions of Caspase-3 in the four groups were 50.0%, 50.0%, 66.7% and 89.5% (P <0.01). The expression of p53 in the four groups was 57.1%, 37.5%, 45.8% and 18.4% respectively (P <0.05). The expressions of Survivin, Caspase-3 and p53 in the four groups were all statistically significance. CONCLUSIONS: The expression of Survivin, Caspase-3 and p53 in the surgical margin of laryngeal carcinoma may play an important role in the occurrence and development of laryngeal squamous cell carcinoma, and is of significance for the early diagnosis and prognosis of laryngeal squamous cell carcinoma.