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在泰国,由于恶性疟原虫对奎宁产生抗性,致使重症疟疾的化疗出现了危机。为此,有必要寻找替代奎宁的非肠道抗疟药物。本文比较了阿莫地喹(Amodiaquine)静脉滴注与阿莫地喹-红霉素口服对恶性疟的疗效。对两组病人在入院治疗前均记录病史并进行血液学、生化以及原虫计数等项检查。病人在原虫消失及药物疗程完毕后出院,并定期返院作有关检查。对阿莫地喹-红霉素组的18例采用体外微量技术测定原虫对氯喹及阿莫地喹的敏感性。阿莫地喹静脉用药组(第1组):年龄在15岁以上,呈中度感染,原虫数一般高于1％。需静脉输液,大多病例伴有恶心、呕吐且不能耐受片剂。双氢氯化
In Thailand, the chemotherapy of severe malaria is at risk due to the resistance of Plasmodium falciparum to quinine. For this reason, it is necessary to find alternative parenteral antimalarial drugs for quinine. This article compares the efficacy of oral administration of amodiaquine and amodiaquine-erythromycin against falciparum malaria. Two groups of patients in the hospital before treatment were recorded history and hematology, biochemistry and protozoa count and other items. The patient was discharged after the protozoa disappeared and the medication was completed, and the hospital was regularly returned to the hospital for inspection. 18 cases of amodiaquine - erythromycin group using in vitro micro - technology to determine protozoa chloroquine and amodiaquine sensitivity. Amoxicillin intravenous drug group (group 1): age over 15 years old, was moderate infection, the number of protozoa generally higher than 1%. Need intravenous infusion, most patients with nausea, vomiting and can not tolerate tablets. Dihydrochlorination