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本文以染色体畸变为观察指标,对人口服3-环戊醚雌二醇(CE_2)24h后的抗放作用进行了实验研究。21名正常人服药24h后,照射其离体血的实验说明,该药对血液系统在服药后24h仍有一定的保护作用。对20名放疗病人的观察说明,服药组的双着丝粒(dic)产额(5.2％)明显低于对照组(18.3％)。根据dic产额推算出对照组病人全身血液的平均受照剂量是1.55Gy,而CE_2服药组只有0.75Gy。因此在本实验条件下,CE_2有降低0.8Gy生物效应的防护作用。文中对所得结果作了简要的讨论。
In this paper, chromosomal aberration as an indicator to test the anti-release effect of oral administration of 3-cyclopentyl ether estradiol (CE_2) 24h. Twenty-one normal subjects took their medicine for 24 hours, and the experiment of irradiation of their blood in vitro showed that the medicine still had some protection to the blood system after taking medicine for 24h. Observations on 20 radiotherapy patients showed that diclofenac (5.2%) in the medication group was significantly lower than in the control group (18.3%). According to the dic output, the average dose of systemic blood in the control group was estimated to be 1.55 Gy, while the CE 2 group only received 0.75 Gy. Therefore, under the experimental conditions, CE_2 has a protective effect of reducing biological effects of 0.8Gy. The results of the article made a brief discussion.