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目的:观察注射用硫普罗宁对慢性病毒性肝炎的临床疗效。方法:在综合治疗的基础上,采用注射用硫普罗宁100～200mg加入5％葡萄糖液250ml中静脉点滴,每日一次,连续用药4～6周。并设肝得健治疗为对照。结果:两组治疗后,主要症状、体征及肝功能指标均明显改善:综合疗效分别为75.0％(36/48)、78.13％(25/32),两组无明显差异,P>0.05。药物不良反应发生率为4.1％(2/48),主要为轻微皮肤症状,不影响治疗。结论:应用硫普罗宁治疗各类肝病疗效确切、安全可靠,与肝得健治疗效果基本相同且较肝得健价廉,值得临床进一步推广、应用。
Objective: To observe the clinical efficacy of tiopronin for chronic viral hepatitis. Methods: On the basis of comprehensive treatment, inject 100 mg of tiopronin into 250 ml of 5% dextrose solution intravenously once daily for 4 to 6 weeks. And liver derma treatment as a control. Results: After treatment, the main symptoms, signs and liver function indexes were significantly improved. The overall curative effect was 75.0% (36/48) and 78.13% (25/32) respectively. There was no significant difference between the two groups (P> 0.05). Adverse drug reaction rate was 4.1% (2/48), mainly minor skin symptoms, does not affect the treatment. Conclusion: The application of tiopronin in the treatment of various liver diseases is effective, safe and reliable. The therapeutic effect is basically the same as that of liver dermabrasion and is cheaper and healthier than the liver, which deserves further promotion and application in clinic.