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目的 :研究奥沙利铂 (L- OHP)与氟尿嘧啶 (5 - Fu)、甲酰四氢叶酸钙 (CF)联合方案治疗晚期并含 5 - Fu方案化疗失败的胃癌和大肠癌的疗效和毒副反应。方法 :L- OHP35 mg/ m2 ,静脉滴注 4 h,d1～ d4 ;5 - FU 5 0 0 mg/ m2 ,静脉滴注 4 h(接 L-OHP) ,d1～ d4 ;CF10 0 mg/ m2 ,静脉滴注 4 h(5 - Fu与 CF从 Y型管同时滴注 ) ,d1～ d4 ,2 1或 2 8天为 1周期。结果 :共治疗 2 2例患者 ,CR1例 ,PR6例 ,SD8例 ,PD7例 ,有效率为 31.8%。各病种的疗效为 :胃癌 2 / 4例 ,大肠癌 2 7.8% (5 / 18)。中位有效缓解期为4个月 (范围 2～ 7个月 )。有 5 4 .5 % (12 / 2 2 )患者在治疗后原有的临床症状有不同程度的改善。主要不良反应为贫血、白细胞和血小板减少、恶心呕吐、口腔炎及末梢神经炎 ,多为 1～ 2度。结论 :奥沙利铂与 5 - Fu、CF联合应用治疗晚期、复治的胃肠道癌疗效确切 ,毒副反应能耐受
OBJECTIVE: To investigate the curative effect and toxicity of gastric cancer and colorectal cancer which failed in the treatment of 5 - Fu containing chemotherapy with 5 - Fu and 5 - Fu combined with 5 - fluorouracil (5 - Fu) side effects. Methods: L-OHP 35 mg / m2, intravenous drip for 4 h, d1-d4; 5-FU 500 mg / m2, iv drip for 4 h , Intravenous drip 4 h (5 - Fu and CF from Y - tube simultaneous instillation), d1 ~ d4, 21 or 28 days for a cycle. Results: A total of 22 patients were treated with CR1, PR6, SD8 and PD7, the effective rate was 31.8%. The curative effects of various diseases were: 2/4 cases of gastric cancer, 2 7.8% (5/18) cases of colorectal cancer. The median effective remission for 4 months (range 2 to 7 months). In 54.5% (12/2 2) of the patients, the original clinical symptoms were improved to some extent after treatment. The main adverse reactions were anemia, leukopenia and thrombocytopenia, nausea and vomiting, stomatitis and peripheral neuritis, mostly 1 to 2 degrees. Conclusion: The combination of oxaliplatin with 5 - Fu and CF in the treatment of advanced and recuperative gastrointestinal cancer is effective and tolerable