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目的:探讨骨碱性磷酸酶测定法对迟发性佝偻病的诊断价值;总结迟发性佝偻病的症状、体征及发病率。方法:对640名10～14岁儿童进行普查,按BALP值分为正常组、可疑组及病例组,随机抽取各组部分样本摄腕关节经X线片,检验BALP与X线符合率,并对可疑组、病例组给予诊断性治疗。对全部样本询问症状、查体,进行统计学处理。结果:640例中正常组423例;可疑组131例;病例组86例。病例组与X线符合率为61.76%,病例组给VitD_3断性试验治疗,2月后复查BALP,72.73%降至250u/L以下。病例组全身乏力、腿痛、腿部足趾抽筋、四肢麻木、O型腿、鸡胸出现率明显高于正常组。结论:BALP测定法为迟发性佝偻病敏感、简易、快速的诊断方法,迟发性佝偻病主要临床表现为全身乏力、腿痛、腿足抽筋、四肢麻木、O型腿和鸡胸。发病率为13.44%。
Objective: To investigate the diagnostic value of bone alkaline phosphatase assay for the diagnosis of delayed rickets, and to summarize the symptoms, signs and incidence of delayed rickets. Methods: A total of 640 children aged 10-14 years were enrolled in this study. The BALP was divided into normal group, suspicious group and case group. Suspicious group, case group given diagnostic treatment. Ask all samples for symptoms, physical examination, for statistical analysis. Results: There were 423 cases in the normal group, 640 cases in the suspicious group and 86 cases in the case group. The coincidence rate of case group and X-ray was 61.76%. The case group was treated with VitD_3 disconnection test. The BALP was re-examined after 2 months, and decreased to below 250u / L after 72.73%. Cases of generalized weakness, leg pain, leg toe cramps, limb numbness, O-shaped legs, chicken breast was significantly higher than the normal group. Conclusion: BALP is a sensitive, simple and rapid diagnostic method for delayed rickets. The main clinical manifestations of delayed rickets are generalized fatigue, leg pain, leg cramps, limb numbness, O-shaped legs and chicken breast. The incidence was 13.44%.