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目的探讨HPV检测在农村妇女宫颈癌筛查中的应用价值。方法收集2014年11月—2015年11月农村宫颈癌筛查妇女20 180名,采用TCT初筛,对ASCUS及以上病变的妇女行HPV-DNA检测并进行宫颈活检。对TCT、HPV、病理学结果进行比较。结果 TCT检查20 180名,正常或宫颈良性病变者占98.7%(19 923/20 180),ASCUS及以上病变者占1.27%(257/20 180),ASCUS在异常宫颈病变中占最高60.7%(156/257)。分析TCT结果与病理学的相关性有统计学意义(P<0.05),显示随着TCT结果病变程度的增高,病理学病变程度也逐渐增高,与TCT的其他结果比较,ASCUS的病理结果呈多样性。分析HPV与病理学的相关性有统计学意义(P<0.05),显示随着病理组织学病变程度的增高,HPV的感染率也逐渐增高。结论 HPV检测在农村妇女宫颈癌筛查中灵敏性较高,值得推广。
Objective To explore the value of HPV testing in screening cervical cancer in rural women. Methods A total of 20 180 women were screened for cervical cancer in rural areas from November 2014 to November 2015. HPV-DNA testing and cervical biopsy were performed on women with ASCUS and above lesions by TCT screening. TCT, HPV, pathological results were compared. Results There were 20 180 cases of TCT, 98.7% (19 923/20 180) cases of normal or benign cervical lesions, 1.27% (257/20 180) cases of ASCUS and above, and ASCUS accounted for the highest 60.7% of cases of abnormal cervical lesions 156/257). The correlation between the results of TCT and pathology was statistically significant (P <0.05), showing that as the degree of pathological changes of TCT results increased, the degree of pathological lesions also gradually increased. Compared with other results of TCT, the pathological results of ASCUS were diversified Sex. The correlation between HPV and pathology was statistically significant (P <0.05), which showed that HPV infection rate gradually increased with the increase of histopathological lesions. Conclusion The detection of HPV in rural women with high sensitivity of cervical cancer screening is worth promoting.