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本文报告1983～1985年的73例乙型肝炎,是根据1984年全国病毒性肝炎会议防治标准;按临床表现、活体肝组织病理检查、血清标志物包括DNA-P以及免疫学等多项指标进行诊断与分型。并将其随机分为二组对比;一组35例应用人白细胞干扰素(IFN-α)治疗,一组38例应用聚肌胞(Poly I:C)治疗。经过3—6月的临床效果观察和免疫功能的检测表明,IFN-α组的总有效率为88.6％31/35例;其中有8例阴转,而Poly I:C组的总有效率为65.8％,未见一例阴转,两组的差异有显著性(P<0.05);并略述其机理。
This article reports 73 hepatitis B cases from 1983 to 1985, based on the 1984 National Conference on Prevention and Treatment of Viral Hepatitis; according to clinical manifestations, pathological examination of living liver tissue, serum markers including DNA-P and immunology Diagnosis and typing. 35 cases were treated with IFN-α, and 38 cases were treated with Poly I: C. After 3 to 6 months of clinical observation and immune function tests showed that IFN-α group, the total effective rate was 88.6% 31/35 cases; of which 8 cases were negative, while Poly I: C group, the total effective rate was 65.8%, no case of overcast, the difference between the two groups was significant (P <0.05); and outlined its mechanism.