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感染D型肝炎病毒(HDV)的同时可感染乙型肝炎病毒。乙型肝炎表面抗原(HBsAg)慢性携带者可重复感染HDV,这往往加重病情,导致慢性活动性肝炎(CAH)和肝硬化。在多数HDV重复感染的病例中发现HDV的增殖,表现为肝细胞核中出现HDV抗原。在这些病例中持续出现IgM抗体和高效价的抗-HDV IgG抗体。Smedile等以Northern吸印法从慢性HDV病人血清中检出HDV RNA。本文报道采用斑点杂交法可检出慢性HDV病人血清中<1pg HDV RNA。
Infection with hepatitis D virus (HDV) can infect hepatitis B virus. Chronic hepatitis B surface antigen (HBsAg) carriers can be repeatedly infected with HDV, which often aggravates the condition, resulting in chronic active hepatitis (CAH) and cirrhosis. HDV proliferation was found in the majority of cases of repeated HDV infections, manifested by the presence of HDV antigens in the nucleus of the liver. IgM antibodies and high titers of anti-HDV IgG antibodies persist in these cases. Smedile et al. Detected HDV RNA from sera of patients with chronic HDV by Northern blotting. This paper reports the detection of <1 pg HDV RNA in sera of chronic HDV patients by dot blot hybridization.