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目的 探讨卡介苗提取液 (唯尔本 )治疗卡介苗 (BCG)接种后结核菌纯蛋白衍生物 (PPD)试验未阳转和T细胞亚群低下的疗效。方法 对PPD阴性者测得T细胞亚群低下的BCG接种后婴儿 6 8例用唯尔本注射液治疗 ,每次 1ml(0 5mg)肌注 ,每周 2次 ,5周为一疗程 ,疗程结束后 2个月复查T细胞亚群及PPD试验。结果 治疗后T细胞亚群CD3、CD4 、CD8、CD4 /CD8较治疗前均明显升高 (P <0 0 1) ,PPD阳转 5 7例 (83 8% )。结论 为提高细胞免疫功能及BCG接种成功率 ,有必要进行免疫调节治疗 ,唯尔本的疗效显著
Objective To investigate the curative effect of Bacillus Calmette-Guerin (UCG) extract on treating untreated tuberculosis and low T lymphocyte subsets in Bacillus Calmette-Guerin (BCG) inoculated with BCG pure protein derivative (PPD). Methods Sixty infants born to BCG vaccinated with low T cell subsets tested for PPD negative were treated with Wolben injection, each intramuscular injection of 1 ml (0 5 mg) twice a week for 5 weeks. The course of treatment Two months after the end of the T cell subpopulation and PPD test. Results After treatment, the levels of CD3, CD4, CD8 and CD4 / CD8 in T cell subsets were significantly higher than those before treatment (P <0.01) and 57 cases (83.8%) in PPD. Conclusion In order to improve the cellular immune function and the success rate of BCG inoculation, it is necessary to carry out immunomodulatory therapy, and Wurben’s effect is significant