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要使抗癌药物发挥疗效,肿瘤必须对该药物敏感,药物在肿瘤的作用部位要有一定的浓度并持续一定的时间。作用部位的药物分布则有赖于药物的吸收,向细胞内进入贮存,代谢及排泄之间的平衡。本文就各类抗癌药物的消化道吸收及在血中浓度,组织内分布、排泄、活化与灭活等特性,以阐明药物临床应用的药代动力学意义。一、烷化剂大部分烷化剂为亲水性,且反应迅速,易于灭
To make the anticancer drug exert its effect, the tumor must be sensitive to the drug. The drug must have a certain concentration in the site of the tumor for a certain period of time. The role of the site of drug distribution depends on the absorption of drugs into the cell into the storage, metabolism and excretion of the balance between. In this paper, various types of anti-cancer drugs in the digestive tract absorption and concentration in the blood, tissue distribution, excretion, activation and inactivation and other characteristics to clarify the clinical pharmacokinetic significance of the drug. First, the alkylating agent Most of the alkylating agent is hydrophilic, and the reaction is rapid, easy to destroy