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甲状腺素对线粒体代谢的影响,近年来引起了广泛的兴趣。这一方面是由于甲状腺素为体内的重要激素,它的分子结构简单但作用复杂,目前的研究已从整体水平、细胞水平进入分子水平,这些知识对于其它激素的作用机制,具有参考的意义。另一方面是由于甲状腺素对线粒体的形态和功能,具有显著的作用,如线粒体的膨胀和收缩,几种重要的部份反应——ATPase~+活力,ATP-~(32)Pi 交换反应等都受到甲状腺素的影响。关于甲状腺素对线粒体的作用机制,近来比较引起注意的有三个假说:(1)甲状腺素对酶具有直接作用(Barler,
The effect of thyroxine on mitochondrial metabolism has aroused widespread interest in recent years. This is due to the fact that thyroxine is an important hormone in the body. Its molecular structure is simple but its function is complex. The current research has entered the molecular level from the overall level and cellular level. This knowledge has reference significance for the mechanism of action of other hormones. On the other hand, thyroxine has significant effects on the morphology and function of mitochondria, such as mitochondrial expansion and contraction, several important partial reactions - ATPase ~ + viability, ATP- ~ (32) Pi exchange reaction, etc. Are affected by thyroxine. There are three hypotheses recently drawn to attention regarding the mechanism of action of thyroxine on mitochondria: (1) Thyroxine has a direct effect on the enzyme (Barler,