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作者采用多微孔的聚烯烃薄膜,进行体外模型的电离子导入研究,观察离子化药物磷酸地塞米松钠、琥珀酸氢化可的松钠、琥珀酸强的松龙钠和非离子化药物醋酸可的松的经膜迁移率。并与药物被动扩散加以对比。因曾有人报道在活体应用电离子导入磷酸地塞米松钠有效,故作本次研究.用于实验的渗透室是并列的两室,其间开一个9 mm 直径的小孔,使0.64cm~2面积的膜,暴露在给药室(Donor cell)和接受室(Receptor cell)之间。
The authors used a microporous polyolefin membrane to study iontophoresis in vitro models and observed the effects of ionizing drugs dexamethasone sodium phosphate, sodium hydrocortisone succinate, sodium citrate succinate, and non-ionizing drug acetate Cortisol’s transmembrane mobility. And passive diffusion of drugs to be compared. It has been reported that in vivo application of iontophoresis into dexamethasone phosphate is effective and was used for this study.The osmotic chamber used for the experiment was a parallel two-chamber system with a 9 mm diameter orifice allowing 0.64 cm ~ 2 Area of the membrane, exposed between the Donor cell and the Receptor cell.