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目的研究铅对豚鼠肾上腺皮质细胞形态与功能影响的毒作用特点及可能的机制。方法选用健康雄性豚鼠以３０ｍｇ／ｋｇ醋酸铅腹腔注射染毒，取血测定皮质醇、醛固酮及ＡＣＴＨ（放免法）、血清胆固醇（酶联法）、血铅和组织铅含量（原子吸收法）和一氧化氮（硝酸还原法）。结果染铅组豚鼠血及组织达到一定铅负荷，激素合成前体胆固醇含量降低、血醛固酮略升而皮质醇和其调控激素ＡＣＴＨ呈降低的趋势，光镜和电镜见肾上腺皮质细胞线粒体与内质网的损伤。结论铅进入机体产生应激反应，同时对束状带产生特异性损伤导致糖皮质激素合成障碍，皮质细胞ＮＯ合成不足可能在铅内分泌毒性过程起重要作用。
Objective To study the toxic effect of lead on the morphology and function of adrenocortical cells in guinea pigs and its possible mechanism. Methods Healthy male guinea pigs were injected intraperitoneally with 30 mg / kg lead acetate for determination of cortisol, aldosterone, ACTH (radioimmunoassay), serum cholesterol (enzyme linked immunosorbent assay), lead and lead in blood (atomic absorption spectrometry) Nitric oxide (nitrate reduction method). Results The blood lead and lead in the lead-exposed guinea pigs were reduced. The cholesterol content of hormone synthesis precursors was decreased, serum aldosterone slightly increased and cortisol and its regulatory hormone ACTH showed a decreasing trend. The mitochondria and endoplasmic reticulum of adrenocortical cells Damage. Conclusion Lead into the body to produce stress response, while the specific damage to the fascia caused glucocorticoid synthesis obstacles, lack of cortical cell NO synthesis may play an important role in lead endocrine toxicity.