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单核细胞因子IL-1是一种有效的结缔组织损伤因子,在慢性炎症中起主要作用。结缔组织损伤和慢性炎症是慢性炎症性牙周病(CIPD)的一个特征。在CIPD中,来自牙斑的细菌产物是如何造成损伤的还不清楚。现已证明至少有一种成伤胞壁二肽具IL—1样作用。本文作者研究了其它细菌胞壁成伤也具有IL—1样活性的可能性;比较了IL—1活性测定的两种方法:淋巴细胞激
Monocyte factor IL-1 is an effective connective tissue injury factor that plays a major role in chronic inflammation. Connective tissue damage and chronic inflammation are a hallmark of chronic inflammatory periodontal disease (CIPD). It is unclear how bacterial products from plaque can cause damage in CIPD. It has been demonstrated that at least one cell wall dipeptide has an IL-1 like effect. The authors studied the possibility that other bacterial cell wall wounds also have IL-1-like activity; two methods of measuring IL-1 activity were compared: lymphocyte activation