环丙氟哌酸对奎尼丁的药代动力学和心电参数的影响

• 作 者: 张孝忠
• 出 处: 国外医药(抗生素分册)
• 发表日期: 1992年02期
• 关键词: 环丙氟哌酸 奎尼丁 药代动力学 酶类药物 加服 间期 荧光偏振 血样 男性健康 导联心电图

作者对环丙氟哌酸和奎尼丁同服后,奎尼丁的药代动力学和心理参数改变进行了研究。8例不吸烟男性健康者参加本试验,年龄22～34岁。试验前48小时未用过其它药物或咖啡类食物,30天内未用过减少肝脏酶类药物。研究分二个阶段,第一阶段单独口服奎尼丁400mg,第二阶段加服环丙氟哌酸750mg,早7:00、晚7:00各服一次,连用5天。

The authors studied the pharmacokinetics and psychological parameters of quinidine after co-administration of ciprofloxacin and quinidine. Eight non-smoking male healthy people participated in the test, aged 22 to 34 years old. 48 hours before the test did not use other drugs or coffee foods, 30 days have not been used to reduce liver enzymes. Study divided into two stages, the first phase of oral administration of quinidine 400mg alone, the second phase plus serving of ciprofloxacin 750mg, as early as 7:00, 7:00 each served once, once every 5 days.