Women carrying germline BRCA1/2 deleterious mutations are an extreme risk population for developing breast cancer,with a cumulative life-time risk of 56-80%
Protein ubiquitination is an important posttranslational modification.Protein ubiquitination is typically sequentially mediated by three enzymes: a ubiquiti
Estrogen synthesis in both benign and malignant human breast tissue is complex, involving several enzyme systems with considerable inter-patient variability