【摘 要】
：
Protein ubiquitination is an important posttranslational modification.Protein ubiquitination is typically sequentially mediated by three enzymes: a ubiquiti
【机 构】
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Center for Cell Biology and Cancer Research Albany Medical College USA
【出 处】
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(BITs 3rd Annual World Cancer Congress-2010, Breast Cancer C
论文部分内容阅读
Protein ubiquitination is an important posttranslational modification.Protein ubiquitination is typically sequentially mediated by three enzymes: a ubiquitin-activating enzyme (E 1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin ligase (E3).The E3 controls substrate specificity.Interestingly, many E3s undergo frequent genetic and expression aberrations and function as either tumor suppressors (i.e., SCFFbw7) or oncoproteins (i.e., Mdm2 and SCFskp2) in breast cancer.Several specific and effective small molecular inhibitors of Mdm2 and CRL have been reported to have a substantial anti-tumor effect in vivo.Therefore, oncogenic E3s are promising molecules for cancer target therapy.
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