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血吸虫童虫膜上一种分子量约为38,000的糖蛋白(38K靶抗原)对包括人在内的多种动物具有强烈的免疫原性。和这种抗原特异性结合的针对曼氏血吸虫的大鼠IgG 2a单克隆抗体IPLSml在嗜碱性粒细胞存在下,对血吸虫具有显著的细胞毒活性,同时对天然大鼠具有高度的被动保护作用。故38K抗原从理论上说是一种非常有效的疫苗材料。但由于这种抗原糖基的存在,限制了DNA重组技术的应用。且38K抗原与保护性抗体一道,在体内、外均可诱导IgG2c抗体产生,该抗体可抑制IPLSml的功能活性。
Schistosoma schistosomula A glycoprotein (38K target antigen) with a molecular weight of about 38,000 is strongly immunogenic for a variety of animals, including humans. The rat IgG2a monoclonal antibody IPLSml against Schistosoma mansoni, which specifically binds to this antigen, has significant cytotoxic activity against Schistosoma japonicum in the presence of basophils while having a high degree of passive protection in native rats . Therefore, the 38K antigen is theoretically a very effective vaccine material. However, due to the presence of this antigen glycosylation, the application of DNA recombination technology is limited. In addition, the 38K antigen, together with the protective antibody, induces IgG2c antibody production both in vitro and in vivo, and this antibody inhibits the functional activity of IPLSml.