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T3分子复合物存在于所有的成熟的人T细胞,其主要成分为一个分子量19～20kd的糖蛋白,此外尚含有28kd、37kd和44kd的分子.与T3复合物反应的单克隆抗体(即OKT3,Leu 4,64.1,UCHT-1)对T细胞的功能具有多种效应,诸如刺激静止T细胞,抑制已为抗原活化的T细胞的反应性等.我们将抗T3复合物的单克隆抗体的作用分为三类:(1)诱导静止T细胞增生;(2)抑制已活化的T细胞克隆对特异的抗原发生反应;(3)阻断细胞毒T细胞的效应功能.上述现象虽可用不同的机制来解释,但也可能涉及到一条共同的通路.
The T3 molecule complex is present in all mature human T cells and consists mainly of a 19-20 kd glycoprotein and 28 kd, 37 kd, and 44 kd molecules. The monoclonal antibody reacted with the T3 complex (ie, OKT3 , Leu 4, 64.1, UCHT-1) have multiple effects on the function of T cells, such as stimulating quiescent T cells, inhibiting the reactivity of T cells that have been activated by antigens, etc. We transferred the anti-T3 complex monoclonal antibody The effects fall into three categories: (1) induction of resting T cell proliferation; (2) inhibition of activated T cell clones on specific antigens; (3) blockade of effector functions of cytotoxic T cells. Mechanism to explain, but may also involve a common pathway.