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本文报告30例HBsAg阳性乙型肝炎患者、40例患者子女、20例正常成人对照组和3例儿童对照组外周血淋巴细胞SCE频率的观察结果,表明:(1)HBsAg阳性乙型肝炎患者SCE率明显高于正常人对照组,差异高度显著(P<0.01);(2)患者发病后出生子女的SCE率明显高于发病前出生子女和正常儿童对照组,差异也非常显著(P<0.01);(3)在患者发病后出生的子女中,母亲发病后与父亲发病后出生的、母亲妊娠期与非妊娠期发病出生的,双亲一方发病后出生的双胞胎与非双胞胎,SCE平均频率均无显著性差异(P>0.05),但是都明显高于患者发病前出生子女的SCE率,差异非常显著(P<0.01)。
This article reports the results of SCE frequency of peripheral blood lymphocytes in 30 HBsAg-positive hepatitis B patients, 40 children, 20 normal controls and 3 children controls. The results show that: (1) SCE in patients with HBsAg-positive hepatitis B (P <0.01). (2) The SCE rate of the children born after the onset of the disease was significantly higher than that of the children born before the onset and the normal children (P <0.01), and the difference was also significant ); (3) Twins and non-twins born after the onset of the illness, the average frequency of SCE were born between the mother and the father after the onset of the disease, the mother was born during pregnancy and non-pregnancy, There was no significant difference (P> 0.05), but both were significantly higher than those before birth in children with SCE rate, the difference was significant (P <0.01).