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为了直接提高靶器官抗生素有效浓度而选择自门静脉途径给药来治疗胆系感染。本文设计了家犬经门静脉间歇推注庆大霉素与外周静脉注射对比,测定血、胆汁、肝组织匀浆中的抗生素浓度分布,结果经门静脉给药,明显提高了肝胆靶器官组织中药物浓度,表明在不增加剂量情况下局部定向给药并耒增加毒性且提高了局部药物浓度,因此作者认为,这是一条良好的治疗胆道感染的给药途径。
In order to directly increase the effective concentration of target organ antibiotics and choose from the portal vein administration to treat biliary tract infection. In this paper, domestic dogs were injected intermittently with intravenous injection of gentamicin and peripheral venous injection contrast, determination of blood, bile, liver homogenate antibiotics concentration distribution, the results of portal vein administration, significantly increased liver and gallbladder target organ tissue drugs Concentration, indicating that local administration does not increase the dose and 耒 increase toxicity and increase the local drug concentration, so the authors believe that this is a good route for the treatment of biliary tract infection.