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目的观察氯吡格雷对不稳定心绞痛的治疗效果。方法选取兰考县中心医院2015年10月—2016年10月收治的80例不稳定心绞痛患者,根据不同用药方法分为两组,每组40例。两组患者入院后均给予常规治疗(阿托伐他汀、硝酸甘油等)。在常规治疗基础上,对照组应用阿司匹林,观察组则应用氯吡格雷。观察比较两组的治疗效果和不良反应情况。结果治疗后观察组患者的心绞痛发作次数、血小板计数、纤维蛋白原水平及药物不良反应率均低于对照组,差异有统计学意义(P<0.05)。1个疗程(30 d)结束后,观察组的治疗总有效率显著高于对照组,差异有统计学意义(P<0.05)。结论在常规治疗基础上,应用氯吡格雷治疗不稳定心绞痛,较应用阿司匹林可有效减缓心绞痛发作次数,药物不良反应少,优良率高。
Objective To observe the effect of clopidogrel on unstable angina pectoris. Methods 80 patients with unstable angina pectoris admitted from October 2015 to October 2016 in Lankao County Central Hospital were divided into two groups (40 cases in each group). Both groups were given routine treatment (atorvastatin, nitroglycerin, etc.) after admission. Based on routine treatment, aspirin was used in the control group and clopidogrel was used in the observation group. Observed and compared the two groups of treatment and adverse reactions. Results After treatment, the number of angina attacks, platelet count, fibrinogen level and adverse drug reaction rate in the observation group were significantly lower than those in the control group (P <0.05). After one course of treatment (30 days), the total effective rate of observation group was significantly higher than that of control group (P <0.05). Conclusion Clopidogrel can be used to treat unstable angina pectoris on the basis of conventional treatment. Compared with aspirin, aspirin can effectively reduce the number of angina pectoris attacks, fewer adverse drug reactions, and excellent and good rate.