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目的研究分析西瓜霜喷剂联合大蒜素治疗鹅口疮的临床效果,并对其治疗安全性进行探讨。方法采用前瞻性病例对照研究方法,选取鹅口疮患儿60例为对照组,均给予2%碳酸氢钠液涂抹患处。同期鹅口疮患儿60例为试验组,均采用西瓜霜喷剂联合大蒜素治疗。治疗期间对两组患儿家属给予健康教育,指导哺乳期卫生,并保持患儿口腔清洁。比较两组临床疗效,并观察治疗期间不良反应发生率。结果两组患儿均完成治疗。试验组有效率为95.0%(57/60),其中痊愈22例,有效35例。对照组有效率为76.7%(46/60),其中痊愈15例,有效31例。对照组有效率低于试验组(P<0.05)。治疗期间试验组患儿出现局部皮肤过敏1例,轻度腹泻1例,发生率为3.3%(2/60);而对照组未见药物不良反应,其发生率差异无统计学意义(P>0.05)。结论西瓜霜喷剂联合大蒜素可有效缓解或消除鹅口疮临床症状,效果明显且安全性较好。
Objective To study the clinical effect of watermelon frost combined with allicin in the treatment of thrush and to discuss the safety of its treatment. Methods A prospective case-control study was conducted. Sixty children with thrush were selected as the control group. All patients were treated with 2% sodium bicarbonate solution. In the same period, 60 children with thrush were treated with watermelon frost combined with allicin. During the treatment of the two families of children with health education, nursing guidance during lactation, and keep the patient’s mouth clean. The clinical efficacy was compared between the two groups and the incidence of adverse reactions was observed during the treatment. Results Both groups completed the treatment. The experimental group was 95.0% (57/60), of which 22 cases were cured and 35 cases were effective. The effective rate of the control group was 76.7% (46/60), of which 15 cases were cured and 31 cases were effective. The effective rate of the control group was lower than that of the experimental group (P <0.05). During the treatment period, there were 1 case of local skin allergy and 1 case of mild diarrhea in the experimental group, the incidence rate was 3.3% (2/60). There was no adverse drug reaction in the control group, and the difference was not statistically significant (P> 0.05). Conclusion Watermelon frost combined with allicin can effectively relieve or eliminate thrush clinical symptoms, the effect is obvious and safe.