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目的 探讨P~(53)、bcl-2蛋白在原发性肺鳞癌中的表达及意义。方法 应用免疫组化方法检测了经5年随访的66例肺鳞癌P~(53)、bcl-2蛋白的表达。结果 P~(53)、bcl-2蛋白在肺鳞癌中的阳性表达率分别为56.1％和27.3％,其中21例有淋巴结癌转移的阳性率分别为61.9％和28.6％。P~(53)和bcl-2蛋白均阳性表达者预后显著差于阴性表达者(P<0.01)。结论 P~(53)和bcl-2蛋白的异常表达与肺鳞癌的生物学行为和随访存活期密切相关,并可作为评估预后的有效指标。
Objective To investigate the expression and significance of P53 and bcl-2 proteins in primary lung squamous cell carcinoma. Methods Immunohistochemistry was used to detect the expression of P53 and bcl-2 protein in 66 cases of lung squamous cell carcinoma after 5 years of follow-up. Results The positive rates of P53 and bcl-2 in lung squamous cell carcinoma were 56.1% and 27.3%, respectively, and the positive rates of metastasis of lymph node metastasis in 21 patients were 61.9% and 28.6%, respectively. The positive expression of P53 and bcl-2 protein was significantly lower than that of negative expression (P<0.01). Conclusion The abnormal expression of P53 and bcl-2 protein is closely related to the biological behavior and follow-up survival of lung squamous cell carcinoma, and it can be used as an effective index to evaluate the prognosis.